Akira Katoh, Yoshimori Omote, Choji Kashima
1984
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0
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Journal
Journal of Heterocyclic Chemistry
Abstract
4,6-Dimethyl-1-phenyl-2(1H)-pyrimidinone (I) was treated with alkyl halides in the presence of sodium hydride at low temperature to afford only C-6 alkylated products III and IV in good yields. Further, the mono-, IIIa-d, and di-alkylated 2(1H)-pyrimidinones IVa-d were selectively obtained by changing the amount of alkyl halides.