M. A. Kaldrikyan, N. S. Minasyan, R. G. Melik-Ogandzhanyan
Nov 8, 2013
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0
Influential Citations
4
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
We previously synthesized 5-[alkoxyphenyl(alkoxyphenethyl, benzofuryl)]-4-phenyl(allyl)-4H-1,2,4triazole-3-thiols some of which (specifically Nand S-substituted derivatives) were found to exhibit antitumor activity [1]. While continuing studies in this line, we tried to find new efficient compounds among substituted 1,2,4-triazole-3-thiols and reveal a possible relation between their chemical structure and antitumor activity. For this purpose, we have synthesized new 1,2,4-triazole-3-thiol derivatives containing a cyclohexyl substituent on C. 1,4-Substituted thiosemicarbazides IIa–IIf were synthesized by heating the corresponding 4-alkoxybenzohydrazides with cyclohexyl isothiocyanate. The cyclization of thiosemicarbazides IIa–IIf in 4.5% aqueous potassium hydroxide gave 5-alkoxyphenyl-4cyclohexyl-4H-1,2,4-triazole-3-thiols IIIa–IIIf which were subjected to S-alkylation with α-halo carboxylic