P. Phukan, A. Sudalai
1999
Citations
0
Influential Citations
7
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Regioselective alkylation of phenol with cyclopentanol is achieved over Montmorillonite K10 clay, producing 2-cyclopentylphenol, the key intermediate. The synthesis of optically active (S)-penbutolol 1, an important antihypertensive drug, is realized in 5 steps from 2-cyclopentylphenol by employing Sharpless asymmetric dihydroxylation.