K. Tishinov, K. Schmidt, D. Häussinger
Nov 26, 2012
Citations
0
Influential Citations
42
Citations
Journal
Angewandte Chemie
Abstract
A variety of nucleic acids can be catalytically alkylated with rhodium-carbenoids generated from diazo compounds in aqueous buffer through an NH insertion process (see scheme; MES=2-(N-morpholino)ethanesulfonic acid). The method specifically targets unpaired bases such as those present in single strands, turn regions, and overhangs while leaving double-stranded sequences untouched.