Yuya A. Lin, J. Chalker, Nicola Floyd
Jul 1, 2008
Citations
2
Influential Citations
263
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second generation catalyst 1. The high reactivity of allyl sulfides in cross-metathesis was exploited in the first examples of cross-metathesis on a protein surface. S-Allylcysteine was incorporated chemically into the protein, providing the requisite allyl sulfide handle. Preliminary efforts to genetically incorporate S-allylcysteine into proteins are also reported.