S. Lang, Kathryn M. O'Nele, J. Tunge
Sep 17, 2014
Citations
0
Influential Citations
155
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
A combination of photoredox and palladium catalysis has been employed to facilitate the room temperature decarboxylative allylation of recalcitrant α-amino and phenylacetic allyl esters. This operationally simple process produces CO2 as the only byproduct and provides direct access to allylated alkanes. After photochemical oxidation, the carboxylate undergoes radical decarboxylation to site-specifically generate radical intermediates which undergo allylation. A radical dual catalysis mechanism is proposed. Free phenylacetic acids were also allylated utilizing similar reactions conditions.