Remko van den Hurk, M. Baghelani, Jie Chen
Sep 1, 2019
Citations
1
Influential Citations
5
Citations
Journal
Sensors and Actuators A: Physical
Abstract
Abstract The functionalization of a nanocomposite AlMo surface with a bifunctional diazonium linker is presented. Binding of diazonium molecules to the AlMo surface was validated through XPS measurements of 4-bromobenzenediazonium tetrafluoroborate and the linking molecule 4-formylbenzene diazonium hexafluorophosphate. The linker was then used to bind monoclonal antibodies specific for bovine herpesvirus-1 (BHV-1) to the AlMo coated chips. BHV-1 was successfully captured on the chip surface. The functionalization process was then implemented on 10 nm thick AlMo membranes and resonance measurements were performed to successfully detect BHV-1. A method for calculating the mass of BHV-1 on the surface of the membranes is presented and validated via finite element analysis.