Bin Zhang, Huixin Yan, Chongfeng Ge
Nov 13, 2018
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0
Influential Citations
2
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Journal
Organic Process Research & Development
Abstract
A robust, safe, and scalable process for the synthesis of 4,6-dichloropyrimidine-5-carbonitrile is described. All of the intermediates in the process are storable under normal conditions. Significant process safety evaluation was undertaken in this route, and the highlights of these studies are presented. This scalable and safe synthetic strategy can be applied for multikilogram-scale production.