Zhu Zhijian, N. Colbry, M. Lovdahl
Aug 21, 2007
Citations
0
Influential Citations
9
Citations
Journal
Organic Process Research & Development
Abstract
Convergent synthesis of 8-fluoronaphthalen-1-ylamine (6) was achieved through the reaction of 1H-naphtho[1,8-de][1,2,3]triazine (15) with HF-pyridine under mild conditions. This new synthesis for the preparation of 6 overcame many scale-up challenges that exist in the methods reported in the literature and provided a practical alternative synthesis of 1-(8-fluoronaphthalen-1-yl)piperazine (1).