L. Prikazchikova, L. I. Rybchenko, S. Klyuchko
Oct 1, 1994
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 2- and 4-hydroxypyrimidines with N-(1,2,2,2-tetrachloroethyl)amides of carboxylic acids in the presence of sodium hydroxide or triethylamine leads to products of amidoalkylation a the N(1) and N(3) atoms respectively. In addition, 2-alkyl-4-hydroxy-pyrimidines give products of O- or C-amidoalkylation with the reagents indicated, evidently caused by steric factors and by kinetic and thermodynamic control.