B. Hamper, E. Tesfu
Aug 13, 2007
Citations
0
Influential Citations
27
Citations
Journal
Synlett
Abstract
Chloropyridines are efficiently converted into 2-amino-pyridines by uncatalyzed nucleophilic aromatic substitution (S N Ar) in NMP using a continuous-flow reactor. A variety of secondary amines undergo S N Ar with both electron-rich and electron-deficient 2-chloropyridines to afford 2-aminopyridines in good to excellent yield. The flow reactor, which provides a short reaction time and high temperatures up to 300 °C, can overcome the activation barrier for reactions with unactivated substrates. Short reaction times result in fewer side products and can afford milligram to multigram -quantities of product using continuous flow.