Tanja Froehr, Christian P. Sindlinger, Ulrich Kloeckner
Jun 21, 2011
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Influential Citations
222
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Quality indicators
Journal
Organic letters
Abstract
An efficient transition-metal-free amination of benzoxazoles has been developed. With catalytic amounts of tetrabutylammoniumiodide (TBAI), aqueous solutions of H(2)O(2) or TBHP as co-oxidant and under mild reaction conditions, highly desirable 2-aminobenzoxazoles were isolated in excellent yields of up to 93%. First mechanistic experiments indicate the in situ iodination of the secondary amine as the putative mode of activation.