M. Pera‐Titus, Feng Shi
Mar 1, 2014
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0
Influential Citations
91
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Quality indicators
Journal
ChemSusChem
Abstract
Amines are key intermediates in the chemical industry with extensive applications in the manufacture of agrochemicals, pharmaceuticals, detergents, fabric softeners, lubricants, polymers, and food additives. The basis of synthetic amine chemistry and amine industry relies on ammonia, and all the organic amines are produced directly or indirectly from this commodity. Excluding the classical process for amine synthesis by direct reaction of ammonia with alkyl halides and the reduction of nitro or nitrile compounds, 2] various processes such as hydroamination, hydroaminomethylation, and reductive amination have been developed and elegant results were obtained. Besides the reactions mentioned above, direct alcohol amination constitutes an attractive process since water is generated as the main byproduct. Indeed, this reaction constitutes a common method for the production of low alkyl chain amines such as N-methyl-, N,N-dimethyl-, and N,N,N-trimethyl-amines in the presence of Brønsted and Lewis acid catalysts (Scheme 1 a). However, the reaction temperature is usu-