Babu G. Sundar, T. Bailey, E. Bacon
Sep 15, 2011
Citations
0
Influential Citations
14
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these efforts, a new class of (S)-2-pyrrolidin-1-ylmethyl-1-pyrrolidinyl amides was identified.