Qiu Huayu
2011
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Journal
Journal of Hangzhou Normal University
Abstract
2-Amino-4,5-dimethyl thiophene-3-acetic ester is an important intermediate for Silthiofam,which is highly efficient pharmacy for wheat disease.This manuscript developed a novel synthetic process for the preparation of 2-amino-thiophene derivatives through aminium salt-promoted Gewald reaction.The desired products,substituted 2-amino-thiophene derivatives,have excellent chemoselectivity and high yields under mild conditions.