Huang Jin
2010
Citations
0
Influential Citations
0
Citations
Journal
Journal of Wuhan University
Abstract
The N-protection of L-Homoserine lactone hydrochloride has been researched with benzyl chloroformate (CbzCl) as amino protecting agent. The yield reached 93% when the solvent was H2O and the base was NaHCO3. This inorganic reaction system excels the organic reaction system remarkably which the solvent is CH2Cl2 and the base is Et3N or pyridine. The result shows that the inorganic reaction system is also better than the organic reaction system when the amino protecting agent is ethyl chloroformate (EocCl) or methyl chloroformate (MocCl). However for MocCl,if the base is NaHCO3,the yield is higher using homogeneous solvent system such as THF/H2O or acetone/H2O than only using H2O as solvent.