M. Jarman, J. Kuszmann, J. A. Stock
Oct 1, 1969
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0
Influential Citations
4
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The 2′(3′)- O -adenosine and -uridine esters of 1-aminocylopentanecarboxylic acid have been prepared. They had no significant effect against an experimental plasma cell tumour in mice, nor did they inhibit protein synthesis in vitro . Each aminoacyl derivative was separated into its two components which were characterized by n.m.r. spectroscopy. No interconversion between the 2′- and 3′-substituted nucleosides occurred, although base catalyzed hydrolosis proceeded at a rate comparable with that of other aminoacyl nucleosides. The possible implications of these findings in protein biosynthesis are discussed. Some related compounds derived from 6-(methylthio) purine are described.