A. Marxer, F. Hofer, U. Salzmann
1969
Citations
0
Influential Citations
5
Citations
Journal
Helvetica Chimica Acta
Abstract
Phtalazines and 4(3H)-phthalazones are aminoalkylated in high yield by 3-dimethylaminopropyl-magnesiumchloride. Phthalazines add only one molecule of the GRIGNARD reagent at the CN-double bond, giving mono-aminoalkylated 1,2-dihydrophthalazines which undergo no further reaction without previous oxydation. Phthalazones react with the carbonyl and the CN-group yielding in one step di-aminoalkylated dihydrophthalazines. The dihydrophthalazines are easily oxydized with K3Fe(CN)6 to the corresponding phthalazines.