S. Ryabukhin, A. S. Plaskon, Sergey Yu. Boron
Feb 1, 2011
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Influential Citations
28
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Journal
Molecular Diversity
Abstract
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.