Guigen Li, K. Sharpless, C. Olsen
Aug 1, 1996
Citations
0
Influential Citations
44
Citations
Journal
Acta chemica Scandinavica
Abstract
The p-toluenesulfonamide derivate of the C-13 side-chain of taxol was prepared on a one third mole scale in a single step from methyl cinnamate. The process employed is catalytic asymmetric aminohydroxylation (catalytic AA). In the present case, there is no work-up other than filtration of the pure product which is insoluble in the reaction mixture. The sulfonamide protecting group is removed by acidic hydrolysis.