H. Śladowska
Nov 1, 1979
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Journal
Il Farmaco; edizione scientifica
Abstract
The synthesis and the structure of some aminomethyl derivatives of 1-cyclohexylbarbituric acids, obtained by the Mannich reaction, are described. Acids, containing a pyrrolidinomethyl group in the position 5 were found to have the barbituric ring in the enolic form, stabilized by a hydrogen bond with the pyrrolidine nitrogen atom. Some of the described compounds displayed antiinflammatory activity.