M. Platts, T. Hanley
May 12, 1956
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
British Medical Journal
Abstract
Aminometradine, sold under the proprietary name of "mictine," has the chemical formula 1-allyl-3-ethyl-6aminouracil, and is one of a series of substituted aminouracils synthesized by Papesch and Schroeder (1951). Imburgia (1952) administered this substance to eight patients with congestive heart failure and observed a satisfactory diuresis in six of these. Kattus et al. (1952) and Spencer and Lloyd-Thomas (1953) also obtained a successful therapeutic result from two very similar compounds, " SC 2614 " and " SC 3088," and found that, apart from causing mild gastro-intestinal upset, these substances were well tolerated and of low toxicity. The present paper deals with the effect of aminometradine on the urine flow and excretion of electrolytes, and the diuretic effect of this drug on a group of patients with congestive heart failure: