O. Uchikawa, K. Fukatsu, T. Aono
Jul 1, 1994
Citations
0
Influential Citations
12
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Treatment of diamides derived from α-amino acids with phosphorus penta- sulfide or Lawesson's reagent was shown to provide a convenient method to prepare 5-aminothiazoles. By this method, in addition to monocyclic 5-aminothiazoles (19), novel bicyclic 5-aminothiazole derivatives such as 4,5,6,7-tetrahydrothiazolo[5,4-b]pyridines (11), 5,6,7,8-tetrahydro- 4H-thiazolo[5,4-b]azepines (7), 4,5,6,7,8,9-hexahydrothiazolo[5,4-b]- azocine (16) and related compounds were prepared in moderate to good yields from simple diamides, suggesting the wide versatility of the method