T. Chang
1958
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Acta Physiological Sinica
Abstract
Experimental studies with a method for testing analgesia adapted from Reinhard, de Beer and Grewal have shown: (1) Both aconitine and andromedotoxin, which are the toxic principles of the Chinese drugs Wu-T'ou(乌头) and Nao-Yang-hua(闹羊花) respectvely, possess definite analgesic action in mice. The minimal analgesic dose of aconitine is 0.025mg/kg and that of andromedotoxin 0.5mg/kg, while the LD_(50), by subcutaneous administration is 0.295mg/kg for aconitine and 4.36mg/kg for andromedotoxin. The analgesic indices of the two principles are therefore, 11.8 for aconitine and 8.6 for andromedotoxin(taking the ratio of LD_(50)/minimal analgesic dose as the analgesic index) (2) The analgesic action of andromedotoxin, demerol and antipyrine is markedly potentiated by scopolamine, while the LD_(50) of andromedotoxin is not significantly altered. (3) The analgesic action of aconitine is also enhanced by scopolamine though to a lesser degree, while the analgesic action of morphine and tetrandrine is not affected. (4) Atropine slightly potentiates the analgesic effect of andromedotoxin, but it doesn't affect that of aconitine. (5) Atropine antagonizes the analgesic action of morphine, and as a result, the potency of morphine is diminished and its action is shortened.