G. P. Hager, R. M. Burgison
1950
Citations
0
Influential Citations
3
Citations
Journal
Journal of the American Pharmaceutical Association
Abstract
A continuation of the study of synthetic analogs of the adrenal cortical hormones has been undertaken. 4,4′-Bis(acetoxyacetyl)-α,α′-diethylstilbene (I) has been prepared by way of the following intermediates: p-bromopropiophenone; p-bromopropiophenone hydrazone; p-bromophenylethyldiazomethane; 1,2-bis(p-bromophenyl)-1,2-diethylethylene sulfone; trans-4,4′-dibromo-α,α′-diethylstilbene; 4,4′-dicyano-α,α′-diethylstilbene; α,α′-diethyl-4,4′-stilbene dicarboxylic acid chloride; 4,4′-bis(diazoacetyl)-α,α′-diethylstilbene. Further studies on the hydrolysis of (I) and the preparation of other derivatives are now in progress.