G. P. Hager, W. C. Liu
1953
Citations
0
Influential Citations
1
Citations
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
A continuation of a previously reported study on the use of chloromethylation products in the preparation of substances of pharmacologic interest has resulted in the preparation of the following amidines: 4,4′-bis(amidinomethyl)-diphenyl ether, 1,3-bis(4-amidinomethylphenoxy)-propane, and 1,5-bis(4-amidinomethylphenoxy)-pentane. The following were also prepared: the bifunctional amino-ether, 4,4′-bis(2-diethylaminoethoxymethyl)-diphenyl ether; the bifunctional amine, 4,4′-bis(2-aminoethyl)-diphenyl ether; and the bifunctional imidazoline, 4,4′-bis(2-methylene-2-imidazoline)-diphenyl ether. The hydrochlorides of all the compounds prepared are being tested for pharmacologic evaluation.