G. Ziakas, E. Rekka, A. Gavalas
Aug 15, 2006
Citations
1
Influential Citations
53
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.