R. Galeazzi, G. Martelli, E. Marcucci
Apr 1, 2010
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0
Influential Citations
13
Citations
Journal
Amino Acids
Abstract
An efficient route was developed for the synthesis of the Fmoc-protected dipeptide 4, isostere of Gly-Gly containing an α-methylene β-amino acid; the conformationally restricted analogues of Leu-enkephalin, 3a, and Met-enkephalin, 3b, respectively, were prepared by changing 4 for Gly2-Gly3 in the native compounds 3a and 3b whose biological activities were significantly lower than the parent compounds.