K. Bischofberger, J. Bull, A. Chalmers
Sep 1, 1987
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Journal
Magnetic Resonance in Chemistry
Abstract
The 500 MHz 1H spectra of the 3‐methyl ethers of estrone, estradiol and their 14α‐methyl analogues were assigned by proton decoupling and analysed by second‐order calculations for chemical shifts and coupling constants. Introduction of a 14α‐Me group effects consistent deshielding of 1,3 diaxially disposed protons. Coupling constant values show characteristic changes for ring D protons, and suggest that some minor perturbation in the H‐9α, ‐11α, ‐11β region is caused by the additional methyl group.