Oguma Takayoshi, Shimamura Kenji, Ushio Yoichi
Sep 15, 1990
Citations
0
Influential Citations
5
Citations
Journal
International Journal of Pharmaceutics
Abstract
Abstract Ceftibuten is a new oral antibiotic currently under clinical investigation. Although this drug is readily absorbed in humans as well as in animals, the process of absorption is frequently observed to be discontinuous in humans. In order to clarify the mechanism of discontinuous absorption, the solubility properties and gastric emptying of the drug were investigated. Plasma concentrations of ceftibuten were determined using a modified compartment model in which dissolution in the gastrointestinal tract and gastric emptying were incorporated based on the results observed. The quality of the curve fitting achieved was comparable with that obtained when using the two-step discontinuous absorption model, thereby indicating how the two processes can cause the discontinuous absorption of ceftibuten.