R. Buhs, Thomas E. Maxim, Nathaniel Allen
1974
Citations
0
Influential Citations
66
Citations
Quality indicators
Journal
Journal of chromatography
Abstract
Abstract Cefoxitin, cephalothin and their deacylated metabolites, decarbamylcefoxitin and deacetylcephalothin, have been quantitatively analyzed in whole human urine using high-performance anion-exchange liquid chromatography wiht UV detection. The rate or excretion and extent of deacylation for the two compounds were determined after intravenous injection with or without probenecid and after intramuscular injection. Recoveries of intact cefoxitin were considerably higher than those of cephalothin in all the cases studied, owing to the almost total resistance of cefoxitin to inactivation by deacylation. Cephalothin was found to be deacylated rapidly and to a relatively large extent.