J. Moyer, C. Handley, R. Seibert
Apr 1, 1957
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0
Influential Citations
10
Citations
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Journal
Annals of the New York Academy of Sciences
Abstract
One concept of the diuretic action of the organomercurial compounds is based on the release of inorganic mercury, which is presumed to be responsible for reversibly inhibiting the sodium chloride reabsorbing mechanism of the renal tubules. Pertinent information concerning the excretory products of mercurial diuretics can be obtained by the aid of adsorption chromatography.' Since meralluride (Alercuhydrin) is the sodium salt of a carboxylic acid, an anionic adsorbent will retain the compound selectively, whereas the decarboxylated residue or released inorganic mercury will pass through the column.' Acid aluminum hydroxide was used as the adsorbent. The excretory products of meralluride were studied on dogs in the laboratory, on normal control human subjects, and on patients with heart failure.