A. Kuwahara, Y. Kuwahara, M. Kadowaki
Jun 1, 1994
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Influential Citations
6
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Quality indicators
Journal
Biomedical Research-tokyo
Abstract
The effect of the newly developed S-HT 3 and S-HT 4 receptor dual antagonist, FK1052 on short-circuit current was investigated using submucosa-mucosa sheets of guinea-pig distal colon. S-Hydroxytryptamine (5-HT) evoked an increase in short-circuit current in a concentration-dependent manner. FK1052 concentration-dependently decreased the S-HT-evoked increase in short-circuit current with pIC 50 value of 8.84±0.1. Specific S-HT 3 antagonists, ondansetron, granisetron and ICS205-930 significantly decreased the 5-HT-evoked increases in short-circuit current with pIC 50 values of 7.92±0.05, 7.65±0.08 and 6.62±0.14, respectively