P. Macheras, A. Rosén
May 1, 1984
Citations
0
Influential Citations
2
Citations
Journal
Die Pharmazie
Abstract
Phenytoin (5,5-diphenyl-2,4-imidazolidinedione) is readily oxidized to benzophenone. Using spiro(fluorene-9,4-imidazolidine)-2',5'-dione or 5-(4'-methoxyphenyl)-5-phenyl-2,4-imidazolidinedione as internal markers the oxidation product can be analyzed by GLC, providing an analytical method for plasma phenytoin which removes the need for preliminary extraction of the drug.