Bi Yun-fen
2013
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Journal of Chinese Mass Spectrometry Society
Abstract
Hypaconitine(HA)is a diester-diterpene type aconitum alkaloid,apotential toxicity alkaloid extracted from Aconitum longtounense T.In this study,the hypaconitine's metabolites in rat liver microsomes were determined by UPLC-MS/MS and a high resolution mass spectrogram(HRMS)method.Sulfaphenazole,α-naphthoflavone,quinidine,ketoconazole,ammonium diethyldithiocarbamate were applied as specific inhibitors for CYP3A、CYP1A2、CYP2D6、CYP3Aand CYP2E1in rat liver microsomes.The results show that seven metabolites of hypaconitine were found and characterized in rat liver microsomal incubations.These metabolites were deduced as 15-dehydrate-HA,8-O-deacetyl-HA,2-hydroxyl-HA,mesaconitine,1-O-demethyl-HA,18-O-demethyl-HA,hydroxyl-8-deacetylHA,respectively.Hypaconitine was mainly metabolized by CYP3A.CYP2C,CYP1A2,CYP2Dand CYP2E1were important CYP isoforms responsible for the metabolism reaction of hypaconitine.