P. Klaffenbach, D. Kronenfeld
Apr 11, 1997
Citations
0
Influential Citations
9
Citations
Journal
Journal of Chromatography A
Abstract
Abstract Isopropyl myristate (tetradecanoic acid isopropyl ester) is commercially available in different qualities with specifications for content as low as 90%. Analysis by gas-liquid chromatography with flame ionization detection revealed up to four impurities exceeding the 0.1% level. Impurities identified by gas chromatography-mass spectrometry were the isopropyl esters of C 12 and C 16 fatty acids (dodecanoic acid and hexadecanoic acid, respectively) and the respective ethyl and methyl ester of C 14 fatty acid (tetradecanoic acid). A relatively high level of impurities was also found in the standard material specified by German pharmacopoeia DAB 10 for calibration of response factors for internal standard quantitation. Therefore, results of quantitative analysis were found to be significantly different depending on the method used for quantitation.