A. Fatmi, G. Williams
1989
Citations
0
Influential Citations
15
Citations
Journal
Drug Development and Industrial Pharmacy
Abstract
AbstractA rapid, sensitive, stability indicating, reversed phase HPLC method for the quantitation of Metoclopramide and its related compounds is described. The sample is extracted in methanol and injected on a reverse phase CIS column with a mobile phase of 0.15M ammonium acetate and acetonitrile (80:20) with Wdetection at 268 nm. The method is highly specific, sensitive and has the ability to separate Metoclopramide from its related compunds; narnely, 4-acetylamino-5-chloro-N[2(diethylamino)ethyll-2-methoxybenzamide hydrochloride and 4-amino-5-chloro-2-methoxybenzoic acid in quantities of up to 10 ucg/mL. The method is highly reproducible with average assay recovery of 104.7 2 1.1%.