D. S. Dresback, J. Gallelli
Dec 1, 1970
Citations
0
Influential Citations
3
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Methods of quantitative analysis by UV spectrophoto-metric, colorimetric, and ionic chloride determination are reported for 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196) in the presence of its degradation products. With the exception of the ionic chloride method of analysis of samples exposed to light, all three methods showed good agreement for stability studies of NSC-82196 in acidic aqueous solutions exposed to light and dark and stored at 25°. A sterile lyophilized hydrochloride salt of NSC-82196 for parenteral use, reconstituted with water for injection, was found to have a t1/2 = 150 min. at 25° and t1/2. = 65 hr. at 4°.