R. Kaur, Harpreet Singh
2018
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Journal
Asian Journal of Chemistry
Abstract
The phenomenon of polymorphism is well known of solids with different arrangement of molecules or conformations in crystal lattice. Conformational polymorphism is commonly observed in flexible molecules mainly due to single bond rotation, ring inversion and inversion of lone pair of electrons about the sp hybridized nitrogen. This conformational flexibility introduces complications either by generating number of conformations or by reducing the tendency of crystallization [1]. Depending upon the environment, thioglycine, like other thioamino acids exist as zwitterionic form in crystal structure or in solution but molecular form in gas phase. Thioglycine acts as H2S donor that uses endogenous molecules as carrier scaffolds of the active moiety and are, thus non-toxic. In contrast to the commonly used H2S donor like NaHS, thioglycine liberate H2S at a slow rate mimicking the sustained endogenous H2S production [2]. Thioglycine exerts cardioprotective effects in Myocardial ischemia/reperfusion in vivo [3]. Thioglycine derivatives act as fungicides. The molecular form of thioglycine has higher conformational mobility due to rotation about intermolecular axes i.e. C-N, C-S and C-C. Thioglycine is the Conformational Analysis of Thioglycine Molecule: A Theoretical Study