A. A. Al-badr, H. El-obeid
1988
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Abstract
Publisher Summary This chapter discusses the primidone. Its generic names are primidon, primidonum, hexamidinum, primaclone, and desoxyphenobarbital. Its trade names are cyral, granmid, lepsiral, liskantin, majsolin, medi-pets, midone, and mylepsine. Its molecular weight is 218.3. Primidone occurs as white odorless crystalline powder with a slightly bitter taste. Its melting range is 279 to 284°C. It is soluble 1 in 2000 of water and 1 in 170 of alcohol, practically insoluble in most other organic solvents. The polarographic determination of primidone and some other drugs have been reported. Primidone in powder and tablet forms was quantitatively determined by ultraviolet spectrometry. Quantiative thin-layer chromatography determination of primidone in biological fluid has been reported. A rapid and quantitative determination of the drug in biological fluids was developed consisting of extracting the drug with chloroform, evaporating to dryness and spilting a chloroform-acetic acid solution of the residue on a thin-layer of silica gel.