D. Smart, J. Jerman
Apr 1, 2000
Citations
3
Influential Citations
104
Citations
Quality indicators
Journal
Trends in pharmacological sciences
Abstract
,methanandamide is approximately ten-fold less potent than anandamide in thisorgan bath model (V. Ralevic, pers.commun.). In keeping with this, wehave shown that methanandamide is alsotenfold less potent than anandamide atactivating the human VR1 (Ref. 4).Szolcsanyi also raises the point thatanandamide is analgesic at concen-trations that do not activate VR1(Ref. 1). This is probably correct, evenallowing for the underestimation of thepotency of anandamide at VR1 out-lined above