C. Supuran, M. Barboiu, C. Luca
1996
Citations
0
Influential Citations
108
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Summary Reaction of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-l,3,4-thiadiazole with 2,4,6-trisubstituted pyrylium salts in molar ratios of 1:1 and 1:2 afforded three series of derivatives which were investigated for their abilities to activate the enzyme carbonic anhydrase (CA). Only compounds possessing free aminoalkyl moieties behaved as strong CA II activators, presumably via a mechanism involving the shuttling of protons between the enzyme active site and the environment.