Yusuf Akbaba, Akın Akıncıoğlu, Hülya Göçer
Feb 1, 2014
Citations
1
Influential Citations
105
Citations
Quality indicators
Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Abstract
Abstract Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (Ki = 46 ± 5.4 µM, r2 = 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (Ki = 94 ± 7.6 µM, r2 = 0.982).