Christopher Millbanks
Apr 15, 2001
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Abstract
[68957-94-8] C9H21O6P3 (MW 318.21) (peptide coupling reagent1) Alternate Name: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide. Physical Data: colorless, water-clear syrup, bp 200 °C/0.3 mmHg. The structure is considered to be a trimer. Solubility: sol dichloromethane, dioxane, THF, DMF, N-methyl-2-pyrrolidinone. Form Supplied in: not commercially available. Preparative Method: prepared in high yield by hydrolysis of propylphosphonic dichloride to propylphosphonic acid, followed by heating and distillation under reduced pressure (eq 1).2 (1) Purification: can be purified by vacuum distillation. Handling, Storage, and Precautions: as a 50% w/v solution in dichloromethane, the anhydride can be stored in a brown bottle for several months.1 It is reported to be relatively nontoxic.1