A. Glass, T. Higgins, D. A. Hunt
Oct 24, 2019
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Journal
Tetrahedron Letters
Abstract
Abstract The reaction of 2-(but-2-enoyl)cyclohexan-1-one 2 with primary amines affords 1-substituted-2,3,5,6,7,8-hexahydroquinolin-4(1H)-ones through a tandem Michael addition/enamine formation reaction sequence at room temperature in high yields. Reaction times are greatly reduced (4–24 h vs. 1–2 h; reflux versus room temperature) when powdered 4 A sieves are used.