Qinghe Gao, Shan Liu, Xia Wu
Jun 2, 2015
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Influential Citations
79
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Quality indicators
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Organic letters
Abstract
A new strategy for the synthesis of 1,3,4-oxadiazoles was established through direct annulation of hydrazides with methyl ketones. It was found that the use of K2CO3 as a base achieves an unexpected and highly efficient C-C bond cleavage. This reaction is proposed to go through oxidative cleavage of Csp(3)-H bonds, followed by cyclization and deacylation.