J. Wong, J. Piwinski, Michael J. Green
Jun 1, 1993
Citations
0
Influential Citations
7
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A Series of pyridine ring substituted 1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta[1,2-b]pyridin-11-ylidene)piperidines which are antagonists of both PAF and histamine were prepared by one of three different methods. Analogs with substituents at C-3 were found to be the best dual antagonists among their corresponding reioisomers. Analogs with an electron donating substituent at the C-3 position are generally better antagonists of both PAF and histamine than analogs with electron withdrawing groups.