Jean Pierre Longue Ekon, Tize Zra, Jules Lobe Songue
Oct 1, 2020
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Phytochemistry Letters
Abstract
Abstract Three new anthraquinone derivatives including (2S, 3R)-1,2,3,4-tetrahydro-2,3,6-trihydroxy-2-methylanthracene-9,10-dione (1), 3,6-dihydroxy-1,2-dimethoxyanthraquinone (2) and 1,6-dihydroxy-2-hydroxymethyl-5-methoxyanthraquinone (3) together with thirteen known compounds including eleven anthraquinones and two triterpenes were isolated from the methanolic crude extract of the stem barks of Morinda lucida. The structures of the new compounds were unambiguously elucidated on the basis of modern NMR spectroscopic methods, as well as by high-resolution mass spectrometry. The known compounds were identified on the basis of their spectral characteristics and by comparison with literature data. The antimicrobial activities of (2S, 3R)-1,2,3,4-tetrahydro-2,3,6-trihydroxy-2-methylanthracene-9,10-dione (1), the methanolic crude extract and its fractions were evaluated against five bacteria and four fungi. The lowest values of the MIC (256 μg/mL) were recorded on Candida parapsilosis, Cryptococcus neoformans for the methanolic crude extract and on Salmonella typhi for the ethyl acetate fraction.