Malathy Br, Pradeep Ps, S. Srividya
2014
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
International journal of pharma and bio sciences
Abstract
The aim of this research is to evaluate antibacterial activities against multi drug resistance pathogens with the prepared anthraquinone (AQ) coated polymeric nanoparticles, chitosan (CS) and poly(lactic acid)(PLA) (CS/PLA-AQ NPs). The preliminary and cold stability study was determined for its drug loading capacity, encapsulation efficiency and in vitro drug release behaviour using UV spectrophotometer. The formulation (CS/PLA-AQ NPs) was tested for its antibacterial effect by disc diffusion method and Minimum bactericidal Concentration (MBC) on Gram negative bacteria's (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus vulgaris) which was found to have higher activity when compared to CS-PLA NPs and bare AQ. The results specified that the nanoparticles formulation is a possible applicant to be considered as an antimicrobial agent in vitro.