A. Woolfson
Dec 1, 1977
Citations
0
Influential Citations
3
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Dimethoxane, 6-acetoxy-2,4-dimethyl-l,3-dioxane, is a preservative used mainly in cosmetic formulations. It is claimed to remain concentrated in the aqueous phase of two-phase systems and to exert a broad-spectrum bactericidal action which is unaffected by such factors as pH of the system and the presence of non-ionic surfactants(Gump and Walter, 1964). Recently, commercial dimethoxane has been shown to consist largely of two 1,3-dioxane isomers, together with small amounts of aldehyde contaminants, acetaldehyde and crotonaldehyde(Woo1fson and Woodside, 1976). In this study, the antibacterial activity of dimethoxane has been assessed with a view to its possible application to the preservation of pharmaceutical systems.